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Dissecting the functions of Ulp1 a SUMO-1 specific protease
Reference
C15586
Principal Investigator / Supervisor
Dr Felicity Zoe Watts
Co-Investigators /
Co-Supervisors
Institution
University of Sussex
Department
Sch of Life Sciences
Funding type
Research
Value (£)
161,800
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
01/02/2005
Duration
36 months
Abstract
Mutants defective in SUMO-1 modification display a range of cellular and nuclear abnormalities, indicating that SUMO-1 modification is likely to be required for several cellular processes. We will use the fission yeast as a model system to study Ulp1, one of two of the organism's SUMO-1 specific proteases. We will establish assays for identifying the major roles of Ulp1 within cells and will undertake genetic screens to investigate the interaction of Ulp1 with other cellular processes such as nucleocytoplasmic trafficking. We will then determine the role of SUMO-1 modification of proteins which interact with Ulp1.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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