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Novel cap-binding proteins in yeast
Reference
C15538
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
178,112
Status
Completed
Type
Research Grant
Start date
01/06/2002
End date
01/06/2005
Duration
36 months
Abstract
We will study two new cap-binding proteins in yeast: (i) One of them, eIF4E2, is closely related to the first translational cap-binding protein we described in Schizosaccharomyces pombe (eIF4E1). We will characterise its interactions with other proteins and with mRNA, and define its physiological role in the context of stress conditions. (ii) The second protein, p36, is a new type of cap-binding factor that has homologous in other eukaryotes. We will characterise the subcellular location and physical/functional interactions of this type of protein in S. pombe and Saccharomyces cerevisiae, study its role in cell-free systems, and perform crystallisation trials.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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