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Identification of a factor required for trafficking of a functional adrenocorticotropin receptor to the cell surface
Reference
C15456
Principal Investigator / Supervisor
Professor Adrian Clark
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Barts and The London School of Medicine
Funding type
Research
Value (£)
308,596
Status
Completed
Type
Research Grant
Start date
28/01/2002
End date
27/06/2005
Duration
41 months
Abstract
Functional studies and studies using green fluorescent protein-tagged ACTH receptor (melanocortin 2 receptor) indicate that this receptor can only be expressed at the cell surface in cell lines that express other melanocortin receptors, or in cell lines of adrenocortical origin. In other cells this receptor is retained in the endoplasmic reticulum. It is proposed that a specific factor is required for correct folding or transport to the cell surface. This project aims to characterise this factor, to identify its approximate site of interaction with the ACTH receptor, and to clone it using the yeast 2-hybrid cloning approach. It is expected that this will reveal the nature of a novel class of molecules that may have implications for other G protein-coupled receptors.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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