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Analysis of chaperonin function in the halophilic archaeon Haloferax volcanii
Reference
C15311
Principal Investigator / Supervisor
Professor Peter Lund
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
184,728
Status
Completed
Type
Research Grant
Start date
08/10/2001
End date
08/10/2004
Duration
36 months
Abstract
The eukaryotic cytosol and the archaea contain the Class II chaperonin complexes called Cct proteins. In eukaryotes, these are hexadecameric complexes of two rings of eight subunits each, encoded by eight essential genes. The archaeal Cct proteins are also double rings, but are encoded by only one, two or three genes. Structural and biochemical data is already available for thermophilic Cct proteins. This project will provide biochemical information for a halophilic Cct protein, and also enable the first genetic analysis of the Cct proteins in an archaeon. This will provide a powerful and simple model for understanding the eukaryotic Cct protein as well as giving insights into assisted protein folding under extreme conditions.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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