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Structure and mechanism of the thylakoidal twin- arginine translocation (Tat) protein transporter
Reference
C15310
Principal Investigator / Supervisor
Professor Colin Robinson
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
175,808
Status
Completed
Type
Research Grant
Start date
04/01/2002
End date
04/01/2005
Duration
36 months
Abstract
The twin-arginine translocation (Tat) system transports folded proteins across thylakoid and bacterial membranes. The translocation mechanism is unique but completely obscure at present. We have now generated a construct which becomes trapped within the translocation channel of the thylakoid Tat system, and which facilitates isolation of the entire complex. This project will involve: (i) determination of the composition of the translocation complex, (ii) analysis of its structure using single particle EM analysis, and (iii) the use of site-specific cross-linkers to precisely identify the components that form the translocation channel.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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