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Molecular biological characterisation of neuronal nicotinic acetylcholine receptors from Drosophila

Reference	C15302
Principal Investigator / Supervisor	Professor Neil Millar
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Neuroscience Physiology and Pharmacology
Funding type	Research
Value (£)	205,300
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	31/12/2004
Duration	37 months

Abstract

Nicotinic acetylcholine receptors (nAChRs) are the principal neurotransmitter receptors mediating excitatory transmission in the insect nervous system and are target sites for the economically important class of neonicotinoid insecticides. This project will exploit information provided by the recently completed genome sequencing of the fruit fly Drosophila melanogaster, to further our understanding of insect nAChRs. Novel putative nAChR subunits will be cloned and, together with previously cloned subunits, will be characterised by heterologous expression in Drosophila S2 cells. The assembly, intracellular trafficking and functional properties of recombinant receptors containing defined combinations of cloned subunit will be investigated.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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