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Protein components and signalling events regulating the lineage restriction of embryonic stem cells to neural stem cells
Reference
C15291
Principal Investigator / Supervisor
Dr Jane Wakeman
Co-Investigators /
Co-Supervisors
Institution
Bangor University
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
192,984
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
Following gastrulation, pluripotent stem cells derived from the inner cell mass of the blastocyst, segregate into the three germ layers. From here, it has been assumed that their potential becomes more restricted as they mature and form tissue and organ specific stem cells. Molecular mechanisms and signalling components regulating this restriction in potency have not been addressed. We will take a proteomic approach to define components involved in signalling the restriction in potency as embryonic stem cells form neural stem cells. We will use the mouse ES cell model, enabling future studies to address function of identified components, and specific components. Definition of components is critical to decipher both mechanisms of tissue specific stem cell generation, and de-differentiation, which may govern a stem cells ability to demonstrate plasticity.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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