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Signalling pathways regulating survival and apoptosis during early murine thymic development
Reference
C15277
Principal Investigator / Supervisor
Dr Denis Alexander
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Immunology
Funding type
Research
Value (£)
248,692
Status
Completed
Type
Research Grant
Start date
07/01/2002
End date
06/07/2005
Duration
42 months
Abstract
The aim of the project is to investigate survival signalling pathways in immature murine thymocytes. To achieve this aim we will utilise a novel CD45-/-p56Lck-Y505F transgenic mouse line expressing a hyperactive p56lck kinase which drives survival signals in the T-lineage. Signalling pathways will be analysed in primary CD45-/-p56Lck-Y505F thymocytes and in thymic lymphoma-derived cell-lines. The effects of forced T cell antigen receptor expression and of inducing the active LckY505F transgene at varying times on a CD45-/- background will also be studied. The project will elucidate the pathways of early thymocyte survival which are critical for the development of the mature T cell repertoire.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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