Award details

Haemolysin E a novel pore-forming toxin

Reference	C15272
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors	Professor Peter Artymiuk
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	197,420
Status	Completed
Type	Research Grant
Start date	13/10/2001
End date	13/10/2004
Duration	36 months

Abstract

The production of toxins that damage host tissues is a vital component of many diseases caused by bacteria. We have begun to characterize the regulation, export and structure-function relationships of a novel pore- forming toxin produced by a range of bacterial pathogens. We propose to investigate: 1. the environmental factors affecting the regulation of hlyE expression; 2. the effects of environment on the export of HlyE; 3. the extent of HlyE:membrane interactions and the nature of the HlyE receptor; 4. the oligomeric state of HlyE and the role of various regions of the protein in assembling and stabilising the pore.; 5. the effects of lipid HlyE; 6. the gating of the HlyE pore. Our ultimate aim is to understand hlyE regulation, how the protein is exported and how it differentiates between bacterial and target membranes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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