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Structure-function relationships in tandem pore potassium channels

Reference	C15267
Principal Investigator / Supervisor	Professor Peter Stanfield
Co-Investigators / Co-Supervisors	Professor Michael Sutcliffe
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	162,452
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	01/12/2004
Duration	36 months

Abstract

The physiological importance of tandem pore potassium channels is little understood, but the number of their isoforms suggests great importance. Their structure has implications for the mechanism whereby potassium ion channels select for potassium ions against other cations in the intracellular and extracellular milieux. Concentrating on the acid sensitive channel TASK-1, we shall study the mechanism of selectivity of tandem pore channels by site directed mutagenesis, examining the effects of changes of structure on the ability to select among different cations. We shall also identify pore lining residues of the transmembrane domains using scanning cysteine accessibility mutagenesis; these residues also help determine which ions permeate.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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