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Spatiotemporal dynamics of agonist-induced plasma membrane recruitment of PIP3 effector proteins
Reference
C15221
Principal Investigator / Supervisor
Professor Peter Cullen
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
171,384
Status
Completed
Type
Research Grant
Start date
02/01/2002
End date
02/01/2005
Duration
36 months
Abstract
Phosphatidylinositol 3,4,5-trisphospphate (PIP3) links cell-surface receptors to an array of cellular responses. A central theme is that agonist activation leads to PIP3 accumulation, which in turn induces translocation and activation of relevant binding proteins. How does a single signal control so many different downstream pathways? One possibility is that receptor-specific differences in PIP3 production coupled with variation in phosphomonoesterase activity generate an array of PIP3 response patterns. Such receptor- specific PIP3 patterns may induce precise spatial, temporal and intensity driven recruitment of PIP3 effectors. This proposal is aimed at examining this spatiotemporal regulation of PIP3 effector recruitment.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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