Award details

A-domain interactions in collagen VI assembly

Reference	C15203
Principal Investigator / Supervisor	Professor Cay Kielty
Co-Investigators / Co-Supervisors	Professor Clair Baldock, Dr Charles Shuttleworth
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	196,820
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2004
Duration	36 months

Abstract

Collagen VI forms extensive microfibrillar networks within virtually all connective tissues. We have shown that its unique assembly pathway, which occurs intracellularly (triple-helical monomers, dimers then tetrameters) and extracellularly (microfibrils), is driven by specific A-domain interactions. This proposal is to use recombinant A-domains to define these interactions that drive intracellular assembly, and to conduct proteomic/cross-linking studies to determine A-domain spatial arrangement in assembled collagen VI. This study will provide crucial mechanistic insights into how A-domains contribute to extracellular matrix assembly.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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