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Functional investigation of the interaction of MDM2 with DNA repair and replication machinery in vitro and in vivo
Reference
C15088
Principal Investigator / Supervisor
Professor Mark Boyd
Co-Investigators /
Co-Supervisors
Dr Nikolina Vlatkovic
Institution
University of Liverpool
Department
Surgery
Funding type
Research
Value (£)
164,000
Status
Completed
Type
Research Grant
Start date
25/06/2001
End date
25/06/2004
Duration
36 months
Abstract
We have discovered that the MDM2 molecule interacts with and stimulates the polymerase activity of DNA polymerases alpha and epsilon. For DNA polymerase epsilon this interaction involves direct binding of the two proteins. The interaction of MDM2 with DNA polymerase alpha was subsequently discovered serendipitously (DNA pol alpha and epsilon co-purify). These are exciting discoveries that have important implications for our understanding of the regulation of DNA synthesis and repair in multicellular organisms. We propose to examine the role of MDM2 in modulating the initiation of DNA synthesis and/or DNA repair in vitro and in vivo in response to both proliferative and genotoxic stimuli.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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