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Intracellular targeting and regulation of gene expression by Exchange-Protein-Activated-by-Cyclic AMP (EPAC)
Reference
C15009
Principal Investigator / Supervisor
Dr Stephen Yarwood
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
204,844
Status
Completed
Type
Research Grant
Start date
12/11/2001
End date
01/03/2005
Duration
40 months
Abstract
Exchange factors for cyclic AMP (EPAC) represent a fundamental new mechanism for the transmission of the cyclic AMP signal within cells. EPAC proteins are activated by directly binding cyclic AMP and specifically activate the small GTPase Rap1. To understand how EPACs control cell function we will 1) determine the structural requirements within EPACs for intracellular targeting and interaction with neuronal proteins and lipid membranes; 2) generate dominant-negative and intracellular targeting mutants of EPACs and test their ability to control intracellular signalling events, such as activation of the ERK pathway; 3) using modern, DNA microarray technology we will determine how EPACs control gene activity through cyclic AMP, endothelial-derived and nerve growth factors activated signalling pathways in PC12 cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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