BBSRC Portfolio Analyser
Award details
Regulation of the intracellular signals activated by HGF/SF
Reference
C14990
Principal Investigator / Supervisor
Professor David Fernig
Co-Investigators /
Co-Supervisors
Dr Malcolm Lyon
Institution
University of Liverpool
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
157,440
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
28/02/2005
Duration
43 months
Abstract
Hepatocyte growth/scatter factor (HGF/SF) induces a pleiotrophic response on its target cells and is a key mediator of mesenchymal-epithelial interactions. It is also an important promoter of metastasis in carcinomas. The glycosaminoglycan (GAG) heparan sulphate modulates at least some of the intracellular signals produced by MET, the tyrosine kinase receptor for HGF/SF. This proposal aims to understand how GAGs regulate the dynamics of the intracellular signals induced by HGF/SF, by characterising the kinetics of phosphorylation, tyrosine kinase activity and down-regulation of both MET and intracellular transducers of MET signals. The functions of GAGs will be revealed by the use of defined HGF/SF-binding fragments of the GAGs.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search