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Decoding calcium signals evoked by different calcium entry pathways
Reference
C14987
Principal Investigator / Supervisor
Professor Colin Taylor
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
186,048
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
30/11/2004
Duration
38 months
Abstract
Why do cells express so many receptor-regulated Ca entry pathways? Are they selectively coupled (Ca synapses) to specific responses? A7r5 cells express three of the important classes of Ca entry pathway, and they are uniquely amenable to manipulation. Because Ca entry regulates organelles (mitochondria, ER) and proteins (calmodulin, adenylyl cyclase), we focus on two examples of each to ask whether different cellular responses are selectively regulated by specific Ca entry pathways. We will simultaneously measure Ca entry through each pathway while recording physiological responses. Our work will establish which Ca entry pathways selectively regulate cellular responses, and allow subsequent analysis of the structural basis of Ca synapses.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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