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Mechanistic studies of internal ribosome entry mediated by cellular IRESs
Reference
C14959
Principal Investigator / Supervisor
Professor Anne Willis
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Biochemistry
Funding type
Research
Value (£)
159,412
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
01/07/2004
Duration
36 months
Abstract
In this study we aim to investigate the mechanisms that are used by cellular Internal Ribosome Entry Segments (IRESs) to initiate protein synthesis. Four eukaryotic IRESs will be used in this investigation i.e. those found in the 5 prime UTRs of c-myc, N-myc, BAG-1 and Apaf-1. This will allow comparisons to be made between IRESs located in transcription factors with those identified in mRNAs whose protein products are associated with apoptosis. The experiments described herein will test i) whether eukaryotic IRESs utilise the same mechanism(s) to initiate internal ribosome entry; ii) the sequence requirements for ribosome landing on eukaryotic IRESs; and iii) whether eukaryotic IRESs use the same protein factors.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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