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Molecular characterization of the interaction between NMDA receptors and the MAGUK family of proteins
Reference
C14952
Principal Investigator / Supervisor
Professor Frances Stephenson
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Dept of Pharmaceutical and Biological Ch
Funding type
Research
Value (£)
163,496
Status
Completed
Type
Research Grant
Start date
20/08/2001
End date
20/08/2004
Duration
36 months
Abstract
The project aims to study the molecular interactions between the ionotrophic subtype of glutamate neurotransmitter receptors, the NMDA receptors, and the MAGUK family of proteins which includes the post-synaptic density protein, PSD-95. It will focus on the elucidation of the mechanism by which co- expression of PSD-95 with NMDA receptors results in enhanced receptor expression together with an apparent decrease in either the glutamate affinity or the channel gating mechanism of NR1-1a/NR2A receptors. The interaction of other members of the MAGUK family with NR1-1a/NR2A will be analysed together with other NMDA receptor subtypes which will include alternative NR1 splice forms and NR2C and NR2D subunits.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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