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Inhibition of beta-amyloid formation using N-methylated peptides
Reference
C14685
Principal Investigator / Supervisor
Professor Andrew Doig
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
197,404
Status
Completed
Type
Research Grant
Start date
01/05/2001
End date
31/01/2005
Duration
45 months
Abstract
Beta-Amyloid (Abeta), 39 to 43 amino acid beta-sheet peptide, aggregates in the brain to form the major component of senile plaques in victims of Alzheimer's disease. Using an 11 amino acid derivative of Abeta that retains the properties of the full length peptide, beta(25-35), we have shown that N-methylated derivatives of beta(25-35) can inhibit amyloid formation and reduce toxicity in the wild-type peptide by binding to the edge of the fibril preventing hydrogen bonding. We will continue this work by studying further N-methylated derivatives of beta(25-35), Abeta and all D amino acid Abeta. Peptides will be assessed on their effects on Abeta structure and toxicity, giving rationally designed potential lead compounds for treatment of Alzheimer's disease.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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