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Molecular mechanisms controlling angiogenic signalling from the sphingosine-1 phosphate receptors edg1 and edg3
Reference
C14576
Principal Investigator / Supervisor
Professor Timothy Palmer
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
194,120
Status
Completed
Type
Research Grant
Start date
17/04/2001
End date
16/04/2004
Duration
36 months
Abstract
Diabetic retinopathy, rheumatoid arthritis and cancer are each associated with excessive angiogenesis, defined as the formation of new capillaries from pre-existing blood vessels. Inhibiting angiogenesis in these diseases will require a detailed molecular understanding of the regulatory factors that direct the maturation of endothelial cells into mature blood vessels. One such factor is the bioactive lipid sphingosine-1-phosphate (SSP), which promotes angiogenesis by binding to two endothelial cell surface SPP receptors termed EDG1 and EDG3. This application aims to identify the cellular and molecular mechanisms by which distinct EDG1- and EDG3-activated signalling pathways are regulated in human endothelial cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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