Award details

Effect on membrane traffic and cell-signalling events by protein 2C

Reference	C14570
Principal Investigator / Supervisor	Professor Martin Ryan
Co-Investigators / Co-Supervisors	Dr Caroline Knox
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	220,604
Status	Completed
Type	Research Grant
Start date	01/02/2001
End date	30/04/2004
Duration	39 months

Abstract

We have made a significant breakthrough in the identification of the host-cell:virus protein binding partners which leads to changes in membrane traffic in picornavirus infected cells. We are requesting resources to determine whether our observations are applicable to other viruses with 2C-like proteins, to fine-map the 2C:D-AKAP2 interacting residues, and to determine the direct consequences of this binding to membrane traffic. We also wish to determine the role of the RGS domain of protein 2C and any effects this may have on cell-signalling events within infected/transfected cells. Our results have already identified one new drug target and our work on the downstream effects of 2C:D-AKAP2 binding may well identify others. This proposed programme of work will make significant contributions to both the cellular-biological and virological areas of research.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search