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Identifying the targets of ERK/MAP kinases that mediate survival downstream of p53 in sympathetic neurons
Reference
C14542
Principal Investigator / Supervisor
Dr Aviva Tolkovsky
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Biochemistry
Funding type
Research
Value (£)
152,960
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
01/07/2004
Duration
36 months
Abstract
In neurons, anti-cancer drugs induce a specific p53-mediated death signalling pathway that is distinct from the death signals induced by trophic factor deprivation. We showed that ERK/MAP kinases (but not Akt) activated by NGF specifically antagonise this p53-dependent death pathway in sympathetic neurons. The proteins targeted by the ERKs and the mechanism of p53-induced killing are unknown. This project aims to identify the p53-specified targets whose actions are antagonised by ERKs using differential kinase screening assays and proteomic techniques. In conjunction the mechanisms by which p53 causes death will be explored. Identifying ERK targets could provide a platform for the development of clinically relevant neuroprotective agents.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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