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The role of phosphatidyl inositol 3-kinase activity in the regulation of islet beta-cell gene expression

Reference	C14442
Principal Investigator / Supervisor	Professor Guy Rutter
Co-Investigators / Co-Supervisors	Professor Peter Cullen
Institution	University of Bristol
Department	Biochemistry
Funding type	Research
Value (£)	157,848
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

Molecular understanding of the regulation of insulin production by pancreatic islet beta-cells is central to the development of new treatments of diabetes mellitus. We have recently demonstrated that Type I phosphatidylinositol 3' kinase (PI 3K) activity is necessary and sufficient for the activation by glucose of preproinsulin and other islet gene expression. We will investigate: 1) The regulation by glucose of PI 3Ks, and phosphatidylinositol (3,4,5) trisphosphate (PIP3) production, in beta-cells; 2) The effect on insulin production of constitutively-active or dominant negative PI 3Ks in islets and transgenic mice; 3) The importance of the lipid versus protein kinase activities of PI 3Ks, and the mechanisms of PI 3K regulation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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