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Investigating the regulation and the role of Class II phosphoinositide 3-kinases in growth factor signalling pathways
Reference
C14421
Principal Investigator / Supervisor
Dr Michael Fry
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
158,020
Status
Completed
Type
Research Grant
Start date
01/07/2001
End date
01/07/2004
Duration
36 months
Abstract
Phosphoinositide 3-kinases (PI3Ks) are linked to diverse cellular events including cell proliferation, survival, motility and intracellular trafficking making them attractive potential targets for therapeutic intervention. This proposal addresses the key issues relating to the recently identified Class II PI3Ks whose contribution to these events remains to be elucidated. Specifically, what are their substrates in vivo, how are they regulated, and what is their cellular role? A combination of biochemical, molecular and whole cell approaches will be utilised to address these questions building upon our observations that they function downstream of growth factor and calcium signals. This work will enhance our understanding of PI3K signalling.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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