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Structure:function analysis of RhoE and identification of its downstream targets

Reference	C14420
Principal Investigator / Supervisor	Professor Anne Ridley
Co-Investigators / Co-Supervisors	Dr Kirsi Riento
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	174,908
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	19/05/2004
Duration	41 months

Abstract

Rho family GTP-binding proteins coordinately regulate actin cytoskeletal organization and cell motility responses. We have shown that overexpression of RhoE leads to loss of actin stress fibres and increased migration speed of epithelial cells. To characterize the signalling mechanisms underlying this response, the proposed study aims first to identify proteins that interact directly with RhoE, and second to determine how RhoE function is regulated in cells by selective mutagenesis of RhoE combined with analysis of its phosphorylation by the RhoA target ROCK. In addition, the effect of RhoE expression on other cell responses regulated by Rho family proteins, including mitogenesis and cell invasion, will be tested.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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