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Supramolecular organisation at immune synapses in human T cell anergy and tolerance

Reference	C14333
Principal Investigator / Supervisor	Professor Daniel Davis
Co-Investigators / Co-Supervisors	Professor Margaret Dallman
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	247,708
Status	Completed
Type	Research Grant
Start date	09/07/2001
End date	08/04/2005
Duration	45 months

Abstract

T and target cell surface proteins accumulate in distinct membrane microdomains at intercellular contacts or immune synapses. The immunoregulatory function of this supramolecular organisation at immune synapses is unknown. DMD produced the first images of immune synapses between living cells. Here we propose to use similar imaging methodology to study the immune synapses triggering and facilitating T cell anergy. In particular, this proposal aims to determine: (a) The immunoregulatory function and supramolecular organisation of T cell-T cell immune synapses. (b) The immunoregulatory function and supramolecular organisation of anergic T cell-APC immune synapses. (c) The suppressive effect of anergic T cells on neighbouring sensitive T cells on neighbouring sensitive T cell-APC immune synapses. (d) The role of co- stimulatory molecules in T cell immune synapse formation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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