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Functional characterisation of PSK a novel STE20-like kinase that regulates actin cytoskeletal organisation and MAPKs
Reference
C14086
Principal Investigator / Supervisor
Dr Jonathan David Morris
Co-Investigators /
Co-Supervisors
Professor Anne Ridley
Institution
King's College London
Department
GKT School of Medicine
Funding type
Research
Value (£)
175,988
Status
Completed
Type
Research Grant
Start date
17/04/2001
End date
17/04/2004
Duration
36 months
Abstract
The STE20/PAK family of kinases provide crucial elements in signalling pathways regulating the actin cytoskeleton, cell motility, adhesion, division, growth, transformation and death. We have recently taken human prostatic carcinomas and identified a novel member of the STE20-like family of kinases which we have called prostate-derived STE20-like kinase (PSK). We have shown that PSK regulates actin cytoskeletal organisation and MAPK pathways and the proposed research will look at the effects of PSK on actin regulation, MAPK signalling pathways and the regulation of cell growth.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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