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Analysis of a putative force generating system involved in cyanobacterial gliding motility
Reference
C13950
Principal Investigator / Supervisor
Dr David Adams
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
186,016
Status
Completed
Type
Research Grant
Start date
21/05/2001
End date
21/05/2004
Duration
36 months
Abstract
We have shown that motile cyanobacteria posses a complex fibrillar array in the cell wall, that we believe serves as the force generating system for gliding motility. The fibrils consist of at least one structural protein (FSP) and several associated proteins (FAPs). This project will: 1) sequence the FSP and FAPs; 2) use sequence data to design oligonucleotide probes for screening cyanobacteria for the FSP and FAP genes; 3) clone and sequence FSP and FAP genes, and generate mutants by insertional mutagenesis; and 4) raise antibodies to FSP and FAPs and use these to localise the proteins within cells and to study the in vitro interactions of FAPs with the fibrils.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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