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Role of phosphorylation in the modulation of thermal sensation

Reference	C13934
Principal Investigator / Supervisor	Professor Peter Anthony McNaughton
Co-Investigators / Co-Supervisors	Dr Vittorio Vellani
Institution	University of Cambridge
Department	Pharmacology
Funding type	Research
Value (£)	209,568
Status	Completed
Type	Research Grant
Start date	16/01/2002
End date	16/01/2005
Duration	36 months

Abstract

The molecular substrate by which painful levels of heat are detected may be the vanilloid receptor, VR1, a novel ion channel which responds to heat, capsaicin and low pH. The response to this stimuli is enhanced (or sensitised) by phosphorylation by the epsilon isoform of protein kinase C, and perhaps also by protein kinase A. The project will determine the residues in VR1 phosphorylated by PKC and PKA, and will investigate which are important in sensitisation

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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