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Study of integrin-linked kinase (ILK) in platelet signal transduction
Reference
C13929
Principal Investigator / Supervisor
Professor Jonathan Gibbins
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
180,384
Status
Completed
Type
Research Grant
Start date
08/01/2001
End date
08/01/2004
Duration
36 months
Abstract
Activation of platelets by collagen binding to glycoprotein VI has been shown to stimulate an increase in the affinity of the integrin alpha2 beta1 for collagen. We have shown that integrin-linked kinase (ILK) is present in human platelets and is regulated by platelet agonists. We hypothesise that this molecule may provide a molecular link between alpha2 beta1 and various platelet agonist signalling pathways. The aim of this project is to study the involvement of ILK in platelet signal transduction, particularly in response to collagen. This will involve the use of biochemistry and molecular biology techniques to characterise the signalling mechanisms that influence ILK activity, and to determine whether ILK is regulated by the integrin alpha2 beta1.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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