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Studies of the Res proteins of Bacillus subtilis and their role in cytochrome c assembly
Reference
C13880
Principal Investigator / Supervisor
Professor Nicolas Le Brun
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Chemistry
Funding type
Research
Value (£)
161,368
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
01/11/2003
Duration
36 months
Abstract
The assembly of c-type cytochromes in bacteria containing the System II pathway, found in Gram-positive and some Gram-negative bacteria, as well as in chloroplasts, is poorly understood. Using Bacillus subtilis as a model organism, a fundamental study of this system is proposed with the aim of: 1) identifying residues important for structure and function by in vivo and in vitro analysis of wild-type and variant proteins; 2) investigating the existence of a Res protein complex in the membrane by probing protein-protein interactions; 3) characterising haem-binding by Res proteins using spectroscopic methods; and 4) initiating structural studies through crystallographic methods and spin-labelling/EPR technology.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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