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Characterisation of the Entamoeba histolytica mitosome
Reference
C13820
Principal Investigator / Supervisor
Dr Jorge Tovar
Co-Investigators /
Co-Supervisors
Institution
Royal Holloway, Univ of London
Department
Biological Sciences
Funding type
Research
Value (£)
188,292
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
29/02/2004
Duration
38 months
Abstract
I recently identified in the amitochondrial protist Entamoeba histolytica a novel organelle of endosymbiotic origin, the mitosome. Phylogenetic and biochemical analyses suggest that the mitosome is related to hydrogenosomes and mitochondria but its physiological functions remain unknown. Using biochemical, gene cloning, and immunodetection methodologies this proposal aims to further characterise the mitosome by identifying additional enzymatic/structural components (which may reveal its physiological functions) and by analysing its morphology and fine structure. A mitosome purification protocol will be implemented and the protein import competence of purified organelles will be assessed using an in vitro protein import assay.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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