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Structure and function of a crenarchaeal ssDNA binding protein
Reference
C13796
Principal Investigator / Supervisor
Prof. Malcolm White
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
183,304
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
31/07/2004
Duration
36 months
Abstract
ssDNA binding proteins (SSBs) play a central role in many DNA repair, replication and recombination processes. We are studying these processes in the archaea, which constitute a useful model system for the equivalent eucaryal pathways. We have identified, cloned and expressed an SSB protein (SsoSSB) from the hyperthermophilic crenarchaeote Sulfolobus solfataricus that has several novel characteristics. We will characterise the structure and function of SsoSSB, using a combination of biochemical and biophysical techniques in routine use in our lab, and will investigate the role of SSB in stimulating the activities of other DNA repair proteins, including a variety of helicases and nucleases we are currently studying.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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