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Award details
Physiological and genetic analysis of Drosophila taste transduction: overlap between visual and chemosensory pathways
Reference
C13756
Principal Investigator / Supervisor
Dr Sylwester Chyb
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
211,584
Status
Completed
Type
Research Grant
Start date
02/10/2000
End date
01/02/2004
Duration
40 months
Abstract
Drosophila tarsal and labellar taste sensilla are involved in evaluation of potential foodsource. While sensilla structure is well studied, little is known about transduction pathways involved. This application proposes a comprehensive study of Drosophila taste transduction involving electrophysiology combined with mutant analysis and use of pharmacological agents activating or blocking elements of known signal transduction cascades. Funding is requested to achieve the following objectives: 1) identify cascade steps involved in gustatory transduction and 2) refine newly developed technique for obtaining primary taste neuron cultures from fly probosces for 3) patch clamp identification and characterisation of ionic currents.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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