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Regulation of the size of the inositol trisphosphate-sensitive calcium stores by parathyroid hormone
Reference
C13743
Principal Investigator / Supervisor
Professor Colin Taylor
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
170,368
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
31/03/2004
Duration
41 months
Abstract
The parathyroid hormone receptor (PTHR1) belongs to a family of receptors that both stimulate cAMP formation and release intracellular Ca stores. The latter often requires neither cAMP-dependent protein kinase (PKA) nor formation of IP3. Our studies of cells transfected with PTHR1 suggest that PTH may be the first example of a hormone controlling the size of the IP3-sensitive Ca stores and so the amplitude and spatial distribution of IP3-evoked Ca signals. We suggest that PTH (and related receptors) stimulate fusion of IP3-sensitive and insensitive Ca stores by a PKA-independent mechanism that probably involves monomeric G proteins. We aim to define the signal linking PTH to Ca signals and establish whether it does cause fusion of Ca stores.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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