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Role of Arf5 and Arf6 in regulated membrane trafficking in adipose cells
Reference
C13723
Principal Investigator / Supervisor
Professor Gwyn William Gould
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
187,664
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
31/07/2005
Duration
57 months
Abstract
The ability of cells to traffic membrane proteins to defined subcellular locations in response to an extracellular stimulus is a major area of research. Insulin induces the regulated trafficking of a range of proteins in adipocytes, including the trafficking of transferrin receptors from endosomes to the cell surface, and the rapid and extensive translocation of Glut4 from a unique Glut4 storage vesicle to the cell surface. The objective of this proposal is to capitalise on recent work from this laboratory which has identified unique roles for ADP-ribosylation factor proteins (ARFs) in these distinct trafficking events. We have shown that ARF6 regulates Glut4 traffic, and that ARF5 functions as a regulator of endosomal trafficking. We will determine how the ARF5 and ARF6 regulate these distinct aspects of membrane trafficking, and identify novel ARF5 effector molecules.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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