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Award details
Regulation and function of elongation factor 2 kinase; a paradigm for a novel family of protein kinases
Reference
C13558
Principal Investigator / Supervisor
Professor Christopher Proud
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
154,692
Status
Completed
Type
Research Grant
Start date
20/11/2000
End date
20/11/2003
Duration
36 months
Abstract
Eukaryotic elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2, which is essential for mRNA translation elongation. eEF2k activity and eEF2 phosphorylation are regulated by hormones and other agents via signalling pathways involving mTOR and MAP kinase. We will study this by identifying phosphorylation sites in eEF2k, mutating them and studying their role in regulating its activity. Nutrients also control eEF2, probably via protein phosphatase 2A, and we will study this. eEF2 is the only known substrate for eEF2k; we will use proven methods to identify other substrates. eEF2k belongs to a novel kinase family and its structure is thus of special interest. We will express eEF2k in E. coli for use in crystallisation trials.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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