Award details

Functional characterisation of a nucleoside transporter in trypanosomes

Reference	C13486
Principal Investigator / Supervisor	Professor Mike Barrett
Co-Investigators / Co-Supervisors	Dr Richard Burchmore, Professor Harry De Koning, Dr C Turner
Institution	University of Glasgow
Department	Infection & Immunity
Funding type	Research
Value (£)	204,792
Status	Completed
Type	Research Grant
Start date	14/04/2000
End date	01/06/2003
Duration	38 months

Abstract

This project aims to functionally characterise a nucleoside transporter from trypanosomes which is homologous to equilibrative nucleoside transporters in mammals. The transporter, termed P2, has been selected for study since it also carries trypanocidal drugs. Resistance to these drugs arises when the transporter is altered so that it no longer accumulates drugs to toxic levels. Mutations have already been identified in the gene encoding this transporter in one drug resistant line. We have several other drug-resistant lines and plan to identify the nature of mutations in these parasites too. The functional impact of each mutation will be identified by site-directed mutagenesis, and expression of mutants in yeast cells and trypanosomes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search