Award details

The role of the N-terminus of neurohypophysial peptide hormone receptors in ligand recognition and agonist selectivity

Reference	C13485
Principal Investigator / Supervisor	Professor Mark Wheatley
Co-Investigators / Co-Supervisors
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	173,268
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/10/2003
Duration	38 months

Abstract

This project will address fundamental questions in peptide hormone receptor research namely how are ligands recognised and in particular, how does this interaction differ for agonists and antagonists? Preliminary experiments from my laboratory have identified an 11 residue sub- domain of the N-terminus of the vasopressin V1a receptor which is critical for binding agonists but not antagonists. Using recombinant expression of mutant receptors and chimeric constructs between the V1a and other receptor subtypes in this family, we will identify which residues in this domain are critical for agonist binding, their role in intracellular signalling and the molecular basis for receptor subtype-specific-agonists.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search