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The role of CD31/PECAM-1 in T cell adhesion migration and survival

Reference	C13448
Principal Investigator / Supervisor	Professor Christopher Buckley
Co-Investigators / Co-Supervisors	Professor Janet Lord, Professor Michael Salmon
Institution	University of Birmingham
Department	Immunity and Infection - Rheumatology
Funding type	Research
Value (£)	154,054
Status	Completed
Type	Research Grant
Start date	02/03/2000
End date	02/03/2003
Duration	36 months

Abstract

The pattern of CD31 expression on T cell subsets and the presence of distinct cytoplasmic domain isoforms suggests an important role for CD31 in addition to its role as a leukocyte-endothelial adhesion molecule. We propose that the differential expression and association of CD31 cytoplasmic tail isoforms with different cytoplasmic signalling adaptors, accounts for the diverse biological functions currently ascribed to CD31 in T cells. To address this we will examine the effect of CD31 expression and ligation on T cell signalling, adhesion and survival. Ultimately this work will help elucidate the molecular basis by which adhesion dependent signals integrate with exogenous mitogenic and survival factors.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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