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Intracellular targeting of secretory immunoglobulins in plants
Reference
C13441
Principal Investigator / Supervisor
Professor Lorenzo Frigerio
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
185,404
Status
Completed
Type
Research Grant
Start date
16/10/2000
End date
16/10/2003
Duration
36 months
Abstract
Plants are an attractive system for the expression of recombinant secretory proteins. Understanding the intracellular localisation and targeting of such proteins is essential to optimise their production. I have recently discovered that the expression of a secretory immunoglobulin (SIgA/G) in tobacco cells results in very inefficient secretion: the bulk of the antibody is retained in an early compartment of the secretory pathway and a proportion of polypeptides is transported to the vacuole. Using SIg/A/G as a model, here I propose to study these cellular events, in particular to elucidate the factors that cause intracellular retention and the signals that promote vacuolar targeting. The results will help clarify how plant cells cope with the expression of foreign proteins, and will help optimising the production of biotechnologically valuable proteins in transgenic plants.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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