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Intracellular targeting of secretory immunoglobulins in plants

Principal Investigator / Supervisor Professor Lorenzo Frigerio
Co-Investigators /
Institution University of Warwick
DepartmentBiological Sciences
Funding typeResearch
Value (£) 185,404
TypeResearch Grant
Start date 16/10/2000
End date 16/10/2003
Duration36 months


Plants are an attractive system for the expression of recombinant secretory proteins. Understanding the intracellular localisation and targeting of such proteins is essential to optimise their production. I have recently discovered that the expression of a secretory immunoglobulin (SIgA/G) in tobacco cells results in very inefficient secretion: the bulk of the antibody is retained in an early compartment of the secretory pathway and a proportion of polypeptides is transported to the vacuole. Using SIg/A/G as a model, here I propose to study these cellular events, in particular to elucidate the factors that cause intracellular retention and the signals that promote vacuolar targeting. The results will help clarify how plant cells cope with the expression of foreign proteins, and will help optimising the production of biotechnologically valuable proteins in transgenic plants.


Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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