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Interaction of eukaryotic chaperonin CCT with polymerising cytoskeletal components
Reference
C13434
Principal Investigator / Supervisor
Dr Martin Carden
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
216,524
Status
Completed
Type
Research Grant
Start date
01/10/2000
End date
31/12/2003
Duration
39 months
Abstract
CCT is required to produce functional actins and tubulins, key basic components of the cytoskeleton. We have some of the first evidence supporting a hypothesis that CCT or its subunits serve important functions in cytoskeletal assembly, beyond well-established roles in de novo polypeptide folding. The proposed studies will confirm this and generate further understanding by continuing the characterisation of the role and actions of CCT subunits in regulating the polymerisation of both microfilaments and microtubules. This will include basic in vitro analyses with purified components, some aiming to unravel mechanistic details, and study of CCT action in a defined in vivo process (microtubule polymerisation from centrosomes).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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