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Tissue distribution regulation and molecular determinants of human vitamin C transporter
Reference
C13385
Principal Investigator / Supervisor
Professor Simon Jarvis
Co-Investigators /
Co-Supervisors
Institution
University of Westminster
Department
Sch of Life Sciences
Funding type
Research
Value (£)
182,672
Status
Completed
Type
Research Grant
Start date
12/10/2000
End date
12/10/2003
Duration
36 months
Abstract
Vitamin C is an essential micronutrient and acts both as a cofactor and as an antioxidant. Recently two rat Na+-independent ascorbic acid transporters have been cloned representing a new transporter family. We have now isolated the human homologues of the rat genes. The aims of the proposal are: 1) to elucidate the tissue and subcellular distribution of the ascorbate transporters using antibodies; 2) to study the possible differential regulation of the two human ascorbate transporters; and 3) to investigate the molecular determinants of the permeant binding site. A better definition of vitamin C transport will help in the utilisation of vitamin C supplements and in our understanding of the mechanism of transport by this new transporter family.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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