Award details

Proteome analysis of intracellular signalling cascades in collagen stimulated blood platelets

Reference	C13330
Principal Investigator / Supervisor	Professor Nicole Zitzmann
Co-Investigators / Co-Supervisors	Dr Raymond Dwek, Professor Steve Watson
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	212,636
Status	Completed
Type	Research Grant
Start date	01/11/2000
End date	01/11/2003
Duration	36 months

Abstract

Platelets are small, anucleate cells that play a critical role in haemostasis, being major players in thrombotic diseases such as stroke and myocardial infarction. The aim of this application is to identify and dissect cell surface receptor signalling cascades regulated by the adhesion molecule collagen. Using the analytical power of modern proteomics technology we will identify novel, platelet-specific proteins, protein:protein interactions and phosphorylation events involved in collagen receptor signalling. Proteomics technology has the power to revolutionise the way that we study signalling events in this anucleate cell, allowing us to make major advances in our understanding of collagen-based signalling cascades.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search