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Molecular characterisation of the principal peptide binding site of PDIp

Reference	C13322
Principal Investigator / Supervisor	Dr Peter Klappa
Co-Investigators / Co-Supervisors	Professor Robert Freedman
Institution	University of Kent
Department	Sch of Biosciences
Funding type	Research
Value (£)	176,224
Status	Completed
Type	Research Grant
Start date	01/12/2000
End date	04/10/2004
Duration	46 months

Abstract

We will characterise, at a molecular level, the principal peptide or non-native protein binding site of the protein folding catalysts PDIp (a protein disulphide isomerase expressed exclusively in the pancreas), by a wide range of biophysical and enzymic methods, in terms of: 1) the specificities and affinities of the binding interaction; 2) the amino acid residues in PDIp involved in peptide binding; and 3) the role of the principal peptide binding site in the enzymic activity. We will apply this knowledge in understanding the specificities of the other members of the protein disulphide isomerase family and to exploit it in the modulation of the binding site to produce unique protein folding catalysts.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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