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Purification and identification of protein kinases associated with clathrin coated vesicles
Reference
C12979
Principal Investigator / Supervisor
Professor George Banting
Co-Investigators /
Co-Supervisors
Professor Anthony Clarke
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
166,176
Status
Completed
Type
Research Grant
Start date
30/05/2000
End date
30/05/2003
Duration
36 months
Abstract
Receptor mediated endocytosis (RME) is dependent upon the formation of a complex, multi- subunit protein coat on the cytosolic face of the plasma membrane. Regulation of assembly and disassembly of this coat is fundamentally important in terms of governing RME and membrane turn-over at the plasma membrane. Recent data suggest that reversible phosphorylation of various components of the coat occur, and that this phosphorylation affects coat formation. Thus, reversible phosphorylation may be a way by which RME is regulated. To date, the endogenous kinase(s) responsible for such phosphorylation has not been identified. We plan to purify and identify the kinase(s) responsible for phosphorylation of coat components.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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