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Characterisation of CIP1 a conserved nuclear protein that is essential for cell viability
Reference
C12944
Principal Investigator / Supervisor
Professor Angus Lamond
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
186,352
Status
Completed
Type
Research Grant
Start date
01/12/1999
End date
01/12/2002
Duration
36 months
Abstract
We propose to use a combination of yeast molecular genetics and mammalian cell biochemistry to characterise the function and interactions of the human CIP 1 protein (hCIP1). We first identified hCIP1 through its interaction with the coiled body protein, p80 coilin, in a yeast 2-hybrid screen. CIP1 is a highly conserved protein with homologues in many species from mammals to archaebacteria. Our analysis of the budding yeast orthologue (yCIP1) shows that it is essential for cell viability and is exclusively nuclear in both yeast and mammals. It is therefore likely that CIP 1 performs an important nuclear function. Our aim is to analyse the role of CIP 1 in the nucleus and to identify its interaction partners.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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