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The role of nuclear dots (ND10) in mammalian cell function and adenovirus infection
Reference
C12930
Principal Investigator / Supervisor
Professor Keith Leppard
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
212,340
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2003
Duration
36 months
Abstract
The PML protein is a principal component of nuclear structures (ND10) which are altered in structure in certain disease states and by virus infection and hence are believed to be important for cell function. The aim of this study is to understand the role of ND10 in normal cell function, probing this through disruption of ND10 by infection by adenovirus type 5. Specifically, the experiments will determine whether alterations in molecular form of PML are functionally significant, whether infection-specific alterations are related to those seen during the cell cycle, what are the interactions which occur between ND10 components and viral proteins and in what cell types/under what growth conditions ND10 disruption is of functional significance.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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