Award details

Structural and functional characterisation of a novel human phosphatidylinositol transfer protein rdgB-beta

Reference	C12923
Principal Investigator / Supervisor	Professor Justin Hsuan
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Ludwig Institute for Cancer Research
Funding type	Research
Value (£)	199,188
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	01/10/2003
Duration	36 months

Abstract

The versatile, eukaryotic, membrane lipid phosphatidylinositol (PtdIns), is a precursor to seven different derivatives with differentially phosphorylated inositol head groups. These subtle modifications are vital to numerous biological processes in all cell types, including acute signalling functions. The provision of PtdIns to these processes is carried out by a family of specific transfer proteins, which probably have distinct functions in vivo. We have cloned two isoforms of a novel human PtdIns transfer protein rdgB beta, which is most closely related to, but clearly structurally distinct from, the human Nir proteins that bind the protein tyrosine kinase Pyk2. This project is concerned with identifying the cellular roles of the two rdgB beta isoforms, which will reveal novel functional, regulatory and mechanistic aspects of PtdIns transfer protein biochemistry.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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