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Role of FtsY in thylakoid protein biogenesis

Reference	C12908
Principal Investigator / Supervisor	Professor Colin Robinson
Co-Investigators / Co-Supervisors	Professor Stephen High
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	170,455
Status	Completed
Type	Research Grant
Start date	06/03/2000
End date	21/11/2003
Duration	45 months

Abstract

The overall aim is to unravel the role played by FtsY in the insertion of hydrophobic proteins into the chloroplast thylakoid membrane. FtsY plays a pivotal role in bacterial membrane protein biogenesis and a chloroplast FtsY homologue has recently been cloned. We propose to capitalise on a major new development: the establishment of the first full reconstitution assay for FtsY-dependent insertion. This assay will be used to (a) establish the 'global' role of FtsY in chloroplasts, (b) elucidate the entire sequence of events in the signal recognition particle/FtsY-dependent insertion pathway and (c) determine in detail for the first time how FtsY facilitates protein insertion into the membrane-bound translocation apparatus.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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